CAS No. 449811-01-2
Batch:
Purity:99.95
Chemical Structure
Check the
Pamapimod
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-(2,4-difluorophenoxy)-2-(1,5-dihydroxypentan-3-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 449811-01-2 | |
| Molecular Formula |
C19H20F2N4O4 |
|
| Molecular Weight (MW) | 406.38 | |
| SMILES | CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO | |
| InChIKey | JYYLVUFNAHSSFE-UHFFFAOYSA-N |
Biological Activity
Pamapimod is a selective inhibitor of p38 MAPK, targeting p38α (IC50 0.014 µM) and p38β (IC50 0.48 µM) with no activity against p38γ or p38δ isoforms. By blocking the p38 MAPK signaling pathway, pamapimod suppresses downstream production of pro-inflammatory cytokines, such as TNF-α and IL-1β, leading to reduced inflammatory signaling and attenuation of disease phenotypes in preclinical models of chronic inflammation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 28 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.