CAS No. 410528-02-8
Batch:
Purity:99.83
Chemical Structure
Check the
Palovarotene
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid | |
|---|---|---|
| CAS Number | 410528-02-8 | |
| Molecular Formula |
C27H30N2O2 |
|
| Molecular Weight (MW) | 414.54 | |
| InChIKey | YTFHCXIPDIHOIA-DHZHZOJOSA-N |
Palovarotene is a selective nuclear retinoic acid receptor γ (RAR-γ) agonist. By selectively activating RAR-γ, it downregulates bone morphogenetic protein (BMP) signaling pathways and represses progenitor chondrocyte differentiation. This mechanism attenuates ectopic endochondral bone formation, thereby reducing heterotopic ossification in cell cultures and preserving limb mobility in murine and rat models of fibrodysplasia ossificans progressiva. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.