CAS No. 23180-57-6

Batch: Purity:99.02
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Paeoniflorin (NSC 178886) Chemical Structure
Chemical Structure
Check the Paeoniflorin (NSC 178886) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate
CAS Number 23180-57-6
Molecular Formula

C23H28O11
Molecular Weight (MW) 480.46
SMILES CC12CC3(C4CC1(C4(C(O2)O3)COC(=O)C5=CC=CC=C5)OC6C(C(C(C(O6)CO)O)O)O)O
InChIKey YKRGDOXKVOZESV-WRJNSLSBSA-N

Ordering Information

Biological Activity

Paeoniflorin is a natural monoterpene glucoside isolated from the root of Paeonia albiflora Pall. with broad anti-inflammatory and immunomodulatory activities. It suppresses cyclooxygenase-2 (COX-2) expression and modulates key downstream signaling pathways, including NF-kB and mTOR. Through these mechanisms, paeoniflorin downregulates pro-inflammatory cytokines, attenuates cellular activation, and alleviates tissue damage across various inflammatory and fibrotic disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 96 mg/mL
Ethanol 96 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.