CAS No. 1809031-84-2

Batch: Purity:99.38
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P62-mediated mitophagy inducer Chemical Structure
Chemical Structure
Check the P62-mediated mitophagy inducer product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(3-iodophenyl)-4-(3-nitrophenyl)triazole
CAS Number 1809031-84-2
Molecular Formula

C14H9IN4O2
Molecular Weight (MW) 392.15
InChIKey LSVWEYNSNZJEGB-UHFFFAOYSA-N

Biological Activity

P62-mediated mitophagy inducer (PMI) is a small-molecule activator of mitophagy that operates independently of Parkin recruitment or mitochondrial membrane potential collapse. By stabilizing Nrf2 and upregulating p62 (SQSTM1) expression via the Nrf2 signaling pathway, PMI forces mitochondria into autophagic degradation. This activation drives mitochondrial quality control downstream of the PINK1/Parkin pathway while maintaining bioenergetic competence across the mitochondrial network. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 26 mg/mL (66.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] East DA, et al. Chem Biol. 2014;21(11):1585-96.

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Note: Technical data last updated: Sep 1, 2026.