CAS No. 882257-11-6
Batch:
Purity:99.91
Chemical Structure
Check the
P5091 (P005091)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone | |
|---|---|---|
| CAS Number | 882257-11-6 | |
| Molecular Formula |
C12H7Cl2NO3S2 |
|
| Molecular Weight (MW) | 348.22 | |
| SMILES | CC(=O)C1=CC(=C(S1)SC2=C(C(=CC=C2)Cl)Cl)[N+](=O)[O-] | |
| InChIKey | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
Biological Activity
P5091 is a selective inhibitor of ubiquitin-specific protease 7 (USP7; and the closely related deubiquitinase USP47. By blocking USP7 activity, P5091 promotes the degradation of MDM2, stabilizes p53, and modulates downstream p53-dependent signaling pathways. This targeted inhibition effectively triggers apoptotic cell death and suppresses cell proliferation in preclinical multiple myeloma models, overcoming resistance to conventional therapeutic agents. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
28 mg/mL
(80.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
35 mg/mL
(100.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.