CAS No. 1618636-37-5

Batch: Purity:99.59
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Ozanimod hydrochloride Chemical Structure
Chemical Structure
Check the Ozanimod hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[3-[(1S)-1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxybenzonitrile;hydrochloride
CAS Number 1618636-37-5
Molecular Formula

C23H24N4O3.ClH
Molecular Weight (MW) 440.92
InChIKey HAOOCAKHSFYDBU-BDQAORGHSA-N

Biological Activity

Ozanimod hydrochloride is a potent sphingosine 1-phosphate (S1P) receptor modulator that acts as a selective agonist of S1P1 and S1P5 receptor subtypes. Upon binding S1P1, it induces receptor internalization and degradation, which blocks lymphocyte egress from lymphoid tissues and reduces circulating lymphocyte counts. This inhibition of immune cell trafficking suppresses neuroinflammatory pathways and attenuates autoimmune disease progression in experimental models of multiple sclerosis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (99.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Scott FL, et al. Br J Pharmacol. 2016;173(11):1778-92.

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Note: Technical data last updated: Sep 1, 2026.