CAS No. 737-52-0

Batch: Purity:99.62
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Oxypeucedanin Chemical Structure
Chemical Structure
Check the Oxypeucedanin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[(2S)-3,3-dimethyloxiran-2-yl]methoxy]furo[3,2-g]chromen-7-one
CAS Number 737-52-0
Molecular Formula

C16H14O5
Molecular Weight (MW) 286.28
SMILES CC1(C(O1)COC2=C3C=CC(=O)OC3=CC4=C2C=CO4)C
InChIKey QTAGQHZOLRFCBU-ZDUSSCGKSA-N

Biological Activity

Oxypeucedanin is a naturally occurring coumarin aglycone that acts as an open-channel blocker of the voltage-gated potassium channel hKv1.5. By directly binding to and inhibiting the open state of hKv1.5 channels, it attenuates ultra-rapid delayed rectifier potassium currents. This inhibition disrupts cardiac cellular repolarization pathways and regulates membrane potential, leading to alterations in action potential duration and suppression of atrial excitability.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 24 mg/mL (83.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.