CAS No. 636-00-0

Batch: Purity:99.99
Check CoA
6-OHDA (Oxidopamine hydrobromide) Chemical Structure
Chemical Structure
Check the 6-OHDA (Oxidopamine hydrobromide) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide
CAS Number 636-00-0
Molecular Formula

C8H11NO3.HBr
Molecular Weight (MW) 250.09
SMILES C1=C(C(=CC(=C1O)O)O)CCN.Br
InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N

Ordering Information

Biological Activity

6-OHDA (Oxidopamine hydrobromide) is a neurotoxic organic compound that targets catecholaminergic systems and acts as a dopamine antagonist. It selectively accumulates in dopaminergic neurons via membrane transporters, inducing reactive oxygen species production, mitochondrial dysfunction, and apoptotic cell death. This targeted neurotoxicity leads to the degeneration of nigrostriatal dopaminergic pathways, enabling its widespread use to establish animal models of Parkinson's disease. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (199.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 13 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.