CAS No. 21256-18-8

Batch: Purity:99.78
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Oxaprozin Chemical Structure
Chemical Structure
Check the Oxaprozin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
CAS Number 21256-18-8
Molecular Formula

C18H15NO3
Molecular Weight (MW) 293.32
SMILES C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
InChIKey OFPXSFXSNFPTHF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) that functions as a cyclooxygenase (COX) inhibitor targeting COX-1 and COX-2. By inhibiting COX-mediated enzymatic activity, oxaprozin blocks the conversion of arachidonic acid into pro-inflammatory prostaglandins. This disruption of the prostaglandin signaling pathway reduces downstream inflammatory mediator release, cellular infiltration, and pain signaling, resulting in attenuated tissue swelling, joint stiffness, and inflammation in arthritis models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 58 mg/mL (197.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 58 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.