OSU-T315 analog

Catalog No.S0271 Synonyms: ILK-IN-1

For research use only.

OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through apoptosis and autophagy.

CAS No. 1333146-24-9

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Biological Activity

Description OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through apoptosis and autophagy.

Protocol (from reference)

Chemical Information

Molecular Weight
Formula
CAS No. 1333146-24-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5

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