CAS No. 2070014-82-1
Batch:
Purity:99.80
Chemical Structure
Check the
Osimertinib dimesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid | |
|---|---|---|
| CAS Number | 2070014-82-1 | |
| Molecular Formula |
C28H33N7O2.2CH4O3S |
|
| Molecular Weight (MW) | 691.82 | |
| InChIKey | RPUCCTLBBCSFEX-UHFFFAOYSA-N |
Osimertinib dimesylate is a potent, mutant-selective, irreversible inhibitor of EGFR kinase, targeting EGFR L858R and EGFR L858R/T790M (IC50 1 nM). By selectively blocking EGFR phosphorylation, it suppresses downstream signaling pathways, inhibits cell proliferation, and induces apoptosis in non-small cell lung cancer models. Furthermore, it demonstrates robust anti-tumor efficacy in mutant EGFR xenograft and transgenic animal models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(2.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(2.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.