CAS No. 114482-86-9
Batch:
Purity:99.94
Chemical Structure
Check the
Oroxin B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 114482-86-9 | |
|---|---|---|
| Molecular Formula |
C27H30O15 |
|
| Molecular Weight (MW) | 594.52 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)COC5C(C(C(C(O5)CO)O)O)O)O)O)O)O)O |
Oroxin B is a naturally occurring flavonoid isolated from Oroxylum indicum with antioxidant and antitumor activities. It selectively induces tumor-suppressive endoplasmic reticulum stress and promotes apoptosis in cancer cells. Treatment with Oroxin B inhibits cell proliferation by suppressing COX-2/VEGF and PI3K/AKT signaling pathways, leading to the downregulation of COX-2, VEGF, PI3K, and phosphorylated AKT along with upregulation of PTEN. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(168.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
100 mg/mL
(168.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.