CAS No. 1297537-33-7
Batch:
Purity:99.26
Chemical Structure
Check the
ORM-15341
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1297537-33-7 | |
|---|---|---|
| Molecular Formula |
C19H17ClN6O2 |
|
| Molecular Weight (MW) | 396.83 | |
| SMILES | CC(C[N]1C=CC(=N1)C2=CC=C(C#N)C(=C2)Cl)NC(=O)C3=N[NH]C(=C3)C(C)=O |
ORM-is a potent and full antagonist of the human androgen receptor (hAR) with an ICof 3and an inhibition constant (Ki) of. By blocking androgen receptor nuclear translocation and downstream transcriptional activity, ORM-disrupts androgen signaling pathways to suppress cellular proliferation in prostate cancer cell lines, including those harboring resistant receptor mutations. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.