CAS No. 2257492-95-6

Batch: Purity:99.32
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OPN expression inhibitor 1 Chemical Structure
Chemical Structure
Check the OPN expression inhibitor 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-benzyl-4-[[(1R,4S,5R,8S,9R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxymethyl]triazole
CAS Number 2257492-95-6
Molecular Formula

C25H33N3O5
Molecular Weight (MW) 455.55
InChIKey QRKZWJMHZFFVGH-UOXUIGFWSA-N

Biological Activity

OPN Expression Inhibitor 1 is a dihydroartemisinin ether derivative containing a 1,2,3-triazole moiety that acts as a selective inhibitor of osteopontin (OPN) expression. By targeting OPN, a key pro-metastatic glycoprotein involved in tumor progression, this compound suppresses downstream signaling pathways essential for cancer cell survival and motility. Consequently, inhibition of OPN expression reduces cell proliferation, migration, and invasive potential in breast cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 30 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.