CAS No. 923287-50-7
Batch:
Purity:99.74
Chemical Structure
Check the
Opicapone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-1,2,4-oxadiazol-5-yl]-3-nitrobenzene-1,2-diol | |
|---|---|---|
| CAS Number | 923287-50-7 | |
| Molecular Formula |
C15H10Cl2N4O6 |
|
| Molecular Weight (MW) | 413.17 | |
| InChIKey | ASOADIZOVZTJSR-UHFFFAOYSA-N |
Biological Activity
Opicapone (BIA 9-1067) is a potent, peripherally selective inhibitor of catechol-O-methyltransferase (COMT). By inhibiting COMT activity, it prevents the peripheral degradation of levodopa, thereby increasing its bioavailability and sustained brain delivery. This sustained inhibition leads to increased dopamine levels in the central nervous system, alleviating motor fluctuations associated with Parkinson's disease models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.