CAS No. 2647949-48-0

Ontunisertib Chemical Structure
Chemical Structure
Check the Ontunisertib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(2,6-difluorophenyl)methyl]-2-[3-(6-methyl-2-pyridinyl)-4-quinolin-4-ylpyrazol-1-yl]acetamide
CAS Number 2647949-48-0
Molecular Formula

C27H21F2N5O
Molecular Weight (MW) 469.49
InChIKey QGXRIRYULXOGDQ-UHFFFAOYSA-N

Biological Activity

Ontunisertib (AGMB-129) is an oral, gastrointestinal-restricted small molecule inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGFβR1). By targeting ALK5, it potently blocks pro-fibrotic TGF-beta signaling pathways locally within the gastrointestinal tract. This target inhibition prevents downstream pro-fibrotic gene expression and extracellular matrix accumulation associated with gastrointestinal tissue fibrosis. [1][2]

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Reference

[1] Inman GJ, et al. Mol Pharmacol. 2002;62(1):65-74.

[2] Akhurst RJ, et al. Nat Rev Drug Discov. 2012;11(10):790-811.

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Note: Technical data last updated: Sep 1, 2026.