CAS No. 486-62-4
Batch:
Purity:99.96
Chemical Structure
Check the
Ononin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 486-62-4 | |
|---|---|---|
| Molecular Formula |
C22H22O9 |
|
| Molecular Weight (MW) | 430.40 | |
| SMILES | COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O |
Ononin is a natural isoflavone glycoside that functions as an anti-inflammatory agent. It attenuates the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, by inhibiting the activation of the NF-κB and MAPK signaling pathways. Consequently, Ononin suppresses inflammatory responses and downstream cellular injury, demonstrating protective effects in lipopolysaccharide-induced inflammatory models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
86 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
86 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.