CAS No. 638132-34-0

Batch: Purity:99.52
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ONO-7300243 Chemical Structure
Chemical Structure
Check the ONO-7300243 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]acetic acid
CAS Number 638132-34-0
Molecular Formula

C28H31NO5
Molecular Weight (MW) 461.55
SMILES CC1=C(C=C(C=C1OC)C(=O)N(CCCC2=CC=CC=C2)CC3=CC=C(C=C3)CC(=O)O)OC
InChIKey WGABOZPQOOZAOI-UHFFFAOYSA-N

Ordering Information

Biological Activity

ONO-7300243 is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist. The compound targets LPA1 to block receptor-mediated signal transduction, suppressing downstream G-protein activation and inhibiting key cellular processes such as migration, proliferation, and survival. Through the inhibition of LPA1-dependent signaling cascades, ONO-7300243 reduces pro-fibrotic signaling and cellular recruitment, contributing to the attenuation of tissue remodeling and fibrotic phenotypes. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 46 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.