CAS No. 103639-04-9

Batch: Purity:99.37
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Ondansetron Hydrochloride Dihydrate Chemical Structure
Chemical Structure
Check the Ondansetron Hydrochloride Dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 103639-04-9
Molecular Formula

C18H19N3O.HCl.2H2O
Molecular Weight (MW) 365.85
SMILES CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.O.O.Cl

Biological Activity

Ondansetron Hydrochloride Dihydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki = with low affinity for dopamine receptors. By blocking 5-HT3 receptors on peripheral vagal nerve terminals and within the central chemoreceptor trigger zone, it suppresses serotonin-mediated neuronal depolarization and downstream emetic signaling pathways without disrupting dopamine-mediated neurotransmission. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 73 mg/mL
Ethanol 40 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Butler A, et al. Br J Pharmacol. 1988;94(2):397-412.

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Note: Technical data last updated: Sep 1, 2026.