CAS No. 75629-57-1
Batch:
Purity:99.8
Chemical Structure
Check the
Oncrasin-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde | |
|---|---|---|
| CAS Number | 75629-57-1 | |
| Molecular Formula |
C16H12ClNO |
|
| Molecular Weight (MW) | 269.73 | |
| SMILES | C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C=O | |
| InChIKey | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
Oncrasin-1 is a potent RNA polymerase II inhibitor with selective antitumor activity against cancer cells harboring K-Ras mutations. It drives abnormal nuclear aggregation of protein kinase C iota (PKC-iota) and suppresses RNA polymerase II transcription in sensitive cells, thereby disrupting downstream signaling pathways and inducing apoptosis in K-Ras-mutated human lung cancer cells.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(200.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.