CAS No. 1807861-48-8
Batch:
Purity:99.87
Chemical Structure
Check the
ONC212
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 11-benzyl-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one | |
|---|---|---|
| CAS Number | 1807861-48-8 | |
| Molecular Formula |
C24H23F3N4O |
|
| Molecular Weight (MW) | 440.46 | |
| SMILES | C1CN(CC2=C1N3CCN=C3N(C2=O)CC4=CC=C(C=C4)C(F)(F)F)CC5=CC=CC=C5 | |
| InChIKey | DFULPGUTXZTYKA-UHFFFAOYSA-N |
ONC212 is a fluorinated imipridone analogue of ONC201 that acts as a selective agonist of GPR132. Activation of GPR132 by ONC212 triggers the integrated stress response, downregulates oxidative phosphorylation, and inhibits cell pro-survival signaling. Consequently, ONC212 demonstrates potent anti-tumor efficacy and suppresses growth across various solid tumors, including pancreatic cancer, as well as hematological malignancies. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.