CAS No. 1357470-29-1
Batch:
Purity:99.96
Chemical Structure
Check the
ON123300
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 8-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile | |
|---|---|---|
| CAS Number | 1357470-29-1 | |
| Molecular Formula |
C24H27N7O |
|
| Molecular Weight (MW) | 429.52 | |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N | |
| InChIKey | VADOZMZXXRBXNY-UHFFFAOYSA-N |
Biological Activity
ON123300 is a potent, ATP-competitive multi-targeted kinase inhibitor targeting CDK4, Ark5 (NUAK1), RET, Fyn, PDGFRβ, and FGFR1. By co-targeting CDK4 and Ark5, ON123300 effectively disrupts cell cycle progression through RB phosphorylation blockade and inhibits downstream AKT/mTOR signaling pathways. Consequently, this compound suppresses tumor cell proliferation, impairs cellular survival, and induces apoptotic cell death across preclinical cancer models, including glioblastoma. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(67.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
11 mg/mL
(25.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
29 mg/mL
(67.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.