CAS No. 865783-95-5
Batch:
Purity:99.51
Chemical Structure
Check the
ON-013100
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenol | |
|---|---|---|
| CAS Number | 865783-95-5 | |
| Molecular Formula |
C19H22O7S |
|
| Molecular Weight (MW) | 394.44 | |
| InChIKey | GHPUSRLWNSTQIK-BQYQJAHWSA-N |
ON-013100 is a benzylstyrylsulfone antineoplastic agent that functions as a potent mitotic inhibitor. It suppresses the expression of CDK4 and cyclin D1 while simultaneously downregulating MDM2 and reducing p53 protein levels. Disruption of these key regulatory components impairs mitogenic signaling pathways, leading to cell cycle arrest and significant inhibition of cancer cell proliferation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.