CAS No. 389139-89-3
Batch:
Purity:99.71
Chemical Structure
Check the
Omadacycline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide | |
|---|---|---|
| CAS Number | 389139-89-3 | |
| Molecular Formula |
C29H40N4O7 |
|
| Molecular Weight (MW) | 556.65 | |
| InChIKey | VJYKVCURWJGLPG-IQZGDKDPSA-N |
Omadacycline is a broad-spectrum aminomethylcycline antibacterial antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. By interfering with aminoacyl-tRNA positioning at the ribosomal A site, omadacycline blocks elongation of polypeptide chains. This mechanism confers potent antibacterial activity against a wide variety of Gram-positive, Gram-negative, anaerobic, and atypical pathogens, suppressing bacterial growth and survival. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(179.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.