CAS No. 1075240-43-5

Batch: Purity:99.58
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Omadacycline tosylate Chemical Structure
Chemical Structure
Check the Omadacycline tosylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;4-methylbenzenesulfonic acid
CAS Number 1075240-43-5
Molecular Formula

C36H48N4O10S
Molecular Weight (MW) 728.85
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C)CNCC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
InChIKey CSLDSXNLUZXVTF-XGLFQKEBSA-N

Ordering Information

Biological Activity

Omadacycline tosylate is a first-in-class aminomethylcycline antibiotic that targets the bacterial 30S ribosomal subunit. By reversibly binding to the 30S subunit, it prevents aminoacyl-tRNA from entering the ribosomal A site, thereby inhibiting bacterial protein synthesis. This mechanism confers broad-spectrum antibacterial activity against various Gram-positive, Gram-negative, and atypical bacterial pathogens, including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (137.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.