CAS No. 1257628-77-5
Batch:
Purity:95.58
Chemical Structure
Check the
Olverembatinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[5,4-b]pyridin-5-yl)ethynyl]benzamide | |
|---|---|---|
| CAS Number | 1257628-77-5 | |
| Molecular Formula |
C29H27F3N6O |
|
| Molecular Weight (MW) | 532.56 | |
| InChIKey | TZKBVRDEOITLRB-UHFFFAOYSA-N |
Biological Activity
Olverembatinib (GZD824) is an orally bioavailable pan-Bcr-Abl inhibitor that targets native Bcr-Abl and Bcr-Abl T315I mutant. It suppresses Bcr-Abl autophosphorylation and downregulates downstream signaling pathways, which effectively inhibits cell proliferation and induces apoptosis in leukemia models. Additionally, it drives significant tumor regression in mouse xenograft models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(187.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.