CAS No. 119615-63-3
Batch:
Purity:99.60
Chemical Structure
Check the
Olprinone Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile;hydrochloride | |
|---|---|---|
| CAS Number | 119615-63-3 | |
| Molecular Formula |
C14H10N4O.ClH |
|
| Molecular Weight (MW) | 286.72 | |
| InChIKey | PWTBMBAQRAOAFF-UHFFFAOYSA-N |
Biological Activity
Olprinone hydrochloride (E-1020) is a potent, selective phosphodiesterase 3 (PDE3) inhibitor with an IC50 value of 0.35 μM. Inhibition of PDE3 prevents cyclic adenosine monophosphate (cAMP) degradation, resulting in elevated intracellular cAMP levels and activation of protein kinase A (PKA) signaling pathways. This activity enhances cardiac muscle contractility and induces vascular smooth muscle relaxation, mediating positive inotropic, vasodilatory, and anti-inflammatory cellular responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 4 mg/mL |
| DMSO |
2 mg/mL
(6.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.