CAS No. 2771246-13-8
Batch:
Purity:98.57
Chemical Structure
Check the
olomorasib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(13aS)-10-chloro-8-fluoro-6-oxo-2-prop-2-enoyl-1,3,4,12,13,13a-hexahydropyrazino[2,1-d][1,5]benzoxazocin-9-yl]-2-amino-7-fluoro-1-benzothiophene-3-carbonitrile | |
|---|---|---|
| CAS Number | 2771246-13-8 | |
| Molecular Formula |
C25H19ClF2N4O3S |
|
| Molecular Weight (MW) | 528.96 | |
| InChIKey | OZUPICRWMLEFCS-LBPRGKRZSA-N |
Olomorasib (LY3537982) is a potent and highly selective second-generation small-molecule inhibitor of GDP-bound KRAS G12C. By preferentially binding to the inactive, GDP-bound state of mutant KRAS G12C, it effectively blocks interaction with downstream effectors and impairs the RAF/MEK/ERK signaling pathway. This target inhibition leads to downstream cell cycle arrest and suppression of cellular proliferation in mutant KRAS G12C-bearing tumor cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.