CAS No. 1353550-13-6

Batch: Purity:99.96
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Olmutinib (BI 1482694) Chemical Structure
Chemical Structure
Check the Olmutinib (BI 1482694) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
CAS Number 1353550-13-6
Molecular Formula

C26H26N6O2S
Molecular Weight (MW) 486.59
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4
InChIKey FDMQDKQUTRLUBU-UHFFFAOYSA-N

Ordering Information

Biological Activity

Olmutinib (BI 1482694) is a third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor that also inhibits Bruton's tyrosine kinase (BTK). It selectively targets activating EGFR mutations and the T790M resistance mutation while sparing wild-type EGFR. By blocking mutant EGFR phosphorylation, Olmutinib downregulates downstream PI3K/AKT and MAPK/ERK signaling pathways, leading to inhibited cell proliferation and induced apoptosis in EGFR-mutant cancer cell lines.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 23 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.