CAS No. 144689-63-4

Batch: Purity:99.94
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Olmesartan Medoxomil Chemical Structure
Chemical Structure
Check the Olmesartan Medoxomil product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 144689-63-4
Molecular Formula

C29H30N6O6
Molecular Weight (MW) 558.59
SMILES CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O

Ordering Information

Biological Activity

Olmesartan medoxomil is a selective angiotensin II type 1 (AT1) receptor antagonist that acts as a prodrug, undergoing rapid hydrolysis to its active metabolite, olmesartan. By selectively blocking angiotensin II binding to vascular AT1 receptors, it inhibits angiotensin II-mediated signaling. This blockade prevents vasoconstriction and aldosterone secretion, attenuating vascular resistance and suppressing downstream renin-angiotensin-aldosterone system pathways to regulate hemodynamics.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (159.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.