CAS No. 579-13-5

Batch: Purity:99.98
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Oligomycin A (MCH 32) Chemical Structure
Chemical Structure
Check the Oligomycin A (MCH 32) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
CAS Number 579-13-5
Molecular Formula

C45H74O11
Molecular Weight (MW) 791.06
SMILES CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
InChIKey MNULEGDCPYONBU-AWJDAWNUSA-N

Ordering Information

Biological Activity

Oligomycin A is a macrolide antibiotic and a selective inhibitor of mitochondrial F1FO-ATP synthase. By binding directly to the Fo subunit of the enzyme complex, Oligomycin A blocks proton translocating channels across the inner mitochondrial membrane, thereby preventing oxidative phosphorylation and ATP synthesis. Consequently, this target blockade disrupts cellular bioenergetics, suppresses ATP-dependent metabolic processes, and induces apoptosis across a wide variety of cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (126.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.