CAS No. 22033-87-0

Batch: Purity:99.89
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Olesoxime (TRO 19622) Chemical Structure
Chemical Structure
Check the Olesoxime (TRO 19622) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 22033-87-0
Molecular Formula

C27H45NO
Molecular Weight (MW) 399.65
SMILES CC(C)CCCC(C)C1CCC2C3CCC4=CC(/CCC4(C)C3CCC12C)=N/O

Ordering Information

Biological Activity

Olesoxime (TRO19622) is a mitochondrial-targeted neuroprotective cholesterol oxime derivative that directly binds to outer mitochondrial membrane proteins, including the voltage-dependent anion channel and translocator protein 18 kDa. Interaction with these mitochondrial targets preserves mitochondrial integrity and prevents permeability transition pore opening mediated by oxidative stress. This block of apoptotic signaling enhances neuronal survival and mitigates motor neuron degeneration. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 80 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.