CAS No. 3000549-26-5
Batch:
Purity:98.51
Chemical Structure
Check the
OICR-8268
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3000549-26-5 | |
|---|---|---|
| Molecular Formula |
C19H14Cl2F2N4O2 |
|
| Molecular Weight (MW) | 439.24 |
OICR-8268 is a potent and reversible chemical ligand targeting the WD40 repeat (WDR) domain of DCAF1. By binding to the WDR domain, it engages the substrate recognition subunit of the CUL4-RBX1-DDB1-DCAF1 E3 ubiquitin ligase complex, modulating downstream target protein ubiquitination and proteasomal degradation pathways to facilitate targeted protein degradation applications in cancer research. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.