CAS No. 853929-59-6
Batch:
Purity:97.19
Chemical Structure
Check the
OGT 2115
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 853929-59-6 | |
|---|---|---|
| Molecular Formula |
C24H16BrFN2O4 |
|
| Molecular Weight (MW) | 495.30 |
Biological Activity
OGT 2115 is a cell-permeable and orally active inhibitor of heparanase with potent anti-angiogenic activity. By blocking heparanase, it prevents the enzymatic degradation of heparan sulfate side chains within the extracellular matrix and basement membrane. This inhibition disrupts growth factor release and endothelial cell remodeling, leading to attenuated pro-angiogenic signaling and suppression of vascular tube formation and tumor-associated angiogenesis. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.