CAS No. 350997-39-6
Batch:
Purity:99.31
Chemical Structure
Check the
OGG1-IN-08
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,4-dichloro-1-benzothiophene-2-carbohydrazide | |
|---|---|---|
| CAS Number | 350997-39-6 | |
| Molecular Formula |
C9H6Cl2N2OS |
|
| Molecular Weight (MW) | 261.13 | |
| SMILES | C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl | |
| InChIKey | HSSHUDKWJRJKPV-UHFFFAOYSA-N |
OGG1-IN-08 is a small-molecule inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1) that effectively decreases both the glycosylase and lyase activities of the target enzyme. By blocking OGG1-mediated base excision repair of oxidative lesions, OGG1-IN-08 impairs the repair of 8-oxoguanine in genomic DNA, altering cellular oxidative stress responses and suppressing downstream proinflammatory gene expression in inflammation pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
52 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.