CAS No. 2231294-96-3
Batch:
Purity:99.81
Chemical Structure
Check the
Opevesostat (ODM208)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-(1,3-dihydroisoindol-2-ylmethyl)-5-[(1-methylsulfonylpiperidin-4-yl)methoxy]pyran-4-one | |
|---|---|---|
| CAS Number | 2231294-96-3 | |
| Molecular Formula |
C21H26N2O5S |
|
| Molecular Weight (MW) | 418.51 | |
| InChIKey | LHVKCOBGLZGRQZ-UHFFFAOYSA-N |
Biological Activity
Opevesostat (ODM208) is a first-in-class, selective, nonsteroidal oral inhibitor of cytochrome P11A1 (CYP11A1). By targeting CYP11A1, the enzyme initiating steroid hormone biosynthesis, opevesostat rapidly and reversibly blocks steroidogenesis. This systemic depletion of steroid hormones disrupts androgen receptor signaling and inhibits cell proliferation in steroid-dependent cancer models, including adrenocortical carcinoma and castration-resistant prostate cancer. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(16.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.