CAS No. 1430723-35-5

Batch: Purity:99.96
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ODM-203 Chemical Structure
Chemical Structure
Check the ODM-203 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
CAS Number 1430723-35-5
Molecular Formula

C26H21F2N5O2S
Molecular Weight (MW) 505.54
SMILES CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=CC(=C4)NS(=O)(=O)C5CC5)C6=C(C=C(C=C6)F)F
InChIKey ZJFCBQXPTQSTCZ-UHFFFAOYSA-N

Ordering Information

Biological Activity

ODM-203 is a potent dual kinase inhibitor targeting fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3, FGFR4) and vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3). By simultaneously blocking FGFR and VEGFR receptor tyrosine kinase signaling, it inhibits downstream RAS-MAPK and PI3K-AKT pathways. This dual pathway inhibition suppresses receptor autophosphorylation, endothelial cell proliferation, migration, and tumor-associated angiogenesis, ultimately impairing tumor growth. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (197.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.