CAS No. 2252271-93-3
Batch:
Purity:98.94
Chemical Structure
Check the
Oditrasertib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-(3,3-difluoro-2,2-dimethylpropanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile | |
|---|---|---|
| CAS Number | 2252271-93-3 | |
| Molecular Formula |
C14H15F2N3O2 |
|
| Molecular Weight (MW) | 295.29 | |
| InChIKey | CSCLQCHKUAMZOY-UHFFFAOYSA-N |
Biological Activity
Oditrasertib is a first-in-class, selective, orally bioavailable, and brain-penetrant inhibitor targeting receptor-interacting serine/threonine-protein kinase 1 (RIPK1). By inhibiting RIPK1 activity, it blocks necroptosis signaling and suppresses RIPK1-mediated neuroinflammatory pathways. This inhibition prevents downstream cell death and neuroinflammation, supporting its investigation in central nervous system disorders such as amyotrophic lateral sclerosis and multiple sclerosis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.