CAS No. 1208319-26-9
Batch:
Purity:99.80
Chemical Structure
Check the
Oclacitinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-methyl-1-[4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]methanesulfonamide | |
|---|---|---|
| CAS Number | 1208319-26-9 | |
| Molecular Formula |
C15H23N5O2S |
|
| Molecular Weight (MW) | 337.44 | |
| InChIKey | HJWLJNBZVZDLAQ-UHFFFAOYSA-N |
Oclacitinib (PF-03394197) is a Janus kinase inhibitor targeting JAK1 (IC50 = 10 nM) with 1.8-fold selectivity over JAK2 and 9.9-fold selectivity over JAK3. By suppressing JAK1 enzymatic activity, it blocks the JAK/STAT signaling pathway downstream of pro-inflammatory cytokines, including IL-31, IL-2, IL-4, IL-6, and IL-13. This targeted inhibition disrupts cytokine-mediated cellular signaling cascades and attenuates downstream inflammatory responses. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.