CAS No. 1640292-55-2
Batch:
Purity:99.84
Chemical Structure
Check the
Oclacitinib maleate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-but-2-enedioic acid;N-methyl-1-[4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]methanesulfonamide | |
|---|---|---|
| CAS Number | 1640292-55-2 | |
| Molecular Formula |
C15H23N5O2S.C4H4O4 |
|
| Molecular Weight (MW) | 453.51 | |
| SMILES | CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3.C(=CC(=O)O)C(=O)O | |
| InChIKey | VQIGDTLRBSNOBV-BTJKTKAUSA-N |
Oclacitinib maleate is an inhibitor of the Janus kinase (JAK) family, targeting JAK members with IC50 values ranging from 10 to 99 nM. It selectively suppresses JAK1-dependent cytokine signaling with IC50 values between 36 and 249 nM, without inhibiting a panel of 38 non-JAK kinases. By blocking JAK family activity, it inhibits downstream STAT protein phosphorylation, thereby suppressing pro-inflammatory cytokine-mediated signaling pathways and cellular immune responses.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(198.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | 18 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.