CAS No. 2382811-41-6
Batch:
Purity:99.10
Chemical Structure
Check the
Ocadusertib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2382811-41-6 | |
|---|---|---|
| Molecular Formula |
C25H25N5O4 |
|
| Molecular Weight (MW) | 459.50 |
Ocadusertib is a potent and selective allosteric receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor. By inhibiting RIPK1 enzymatic activity, it blocks necroptotic cell death mediated by the RIPK1/RIPK3/MLKL signaling axis. Targeted inhibition of RIPK1 prevents TNF-induced necroptosis and attenuates downstream pro-inflammatory cytokine release, serving as a functional probe for dissecting programmed necrosis and necroinflammatory disease cascades. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.