CAS No. 851723-84-7
Batch:
Purity:99.5
Chemical Structure
Check the
OC000459
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 851723-84-7 | |
|---|---|---|
| Molecular Formula |
C21H17FN2O2 |
|
| Molecular Weight (MW) | 348.37 | |
| SMILES | CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3 |
OC000459 is a potent and selective D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist with an IC50 of 13 nM. By blocking prostaglandin D2 binding to DP2 receptors, it suppresses G protein-coupled receptor signaling in immune effector cells. This inhibition prevents the activation, chemotaxis, and cytokine production of TH2 lymphocytes, eosinophils, and basophils, thereby suppressing allergic inflammatory cascades.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(11.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.