CAS No. 477-85-0
Batch:
Purity:99.92
Chemical Structure
Check the
Obtusifolin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione | |
|---|---|---|
| CAS Number | 477-85-0 | |
| Molecular Formula |
C16H12O5 |
|
| Molecular Weight (MW) | 284.26 | |
| SMILES | CC1=CC2=C(C(=C1O)OC)C(=O)C3=C(C2=O)C=CC=C3O | |
| InChIKey | NYRXUBDGDSRBGB-UHFFFAOYSA-N |
Obtusifolin is a naturally occurring anthraquinone derivative isolated from the seeds of Cassia obtusifolia that functions as an inhibitor of aldose reductase. By suppressing aldose reductase activity, obtusifolin blocks the polyol pathway and exhibits inhibitory effects against platelet aggregation. These downstream actions contribute to reduced oxidative stress and the modulation of vascular and inflammatory responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(87.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
16 mg/mL
(56.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.