CAS No. 866399-87-3
Batch:
Purity:98.43
Chemical Structure
Check the
Obicetrapib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[2-[[3,5-bis(trifluoromethyl)phenyl]methyl-[(2R,4S)-1-ethoxycarbonyl-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinolin-4-yl]amino]pyrimidin-5-yl]oxybutanoic acid | |
|---|---|---|
| CAS Number | 866399-87-3 | |
| Molecular Formula |
C32H31F9N4O5 |
|
| Molecular Weight (MW) | 722.60 | |
| InChIKey | NRWORBQAOQVYBJ-GJZUVCINSA-N |
Biological Activity
Obicetrapib (TA-8995) is a potent and selective inhibitor of cholesteryl ester transfer protein (CETP). By suppressing CETP-mediated neutral lipid exchange between lipoprotein particles, it significantly increases high-density lipoprotein cholesterol (HDL-C) levels while decreasing non-HDL cholesterol, low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B concentrations. These systemic lipid-modifying alterations enhance anti-atherogenic lipoprotein profiles and support overall cardiovascular risk reduction. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(138.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.