CAS No. 803712-67-6

Batch: Purity:99.82
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Obatoclax (GX15-070) Chemical Structure
Chemical Structure
Check the Obatoclax (GX15-070) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole
CAS Number 803712-67-6
Molecular Formula

C20H19N3O
Molecular Weight (MW) 317.38
SMILES COC1=CC(=NC1=CC2=C(C)C=C(C)[NH]2)C3=CC4=C([NH]3)C=CC=C4
InChIKey CVCLJVVBHYOXDC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Obatoclax (GX15-070) is a potent pan-Bcl-2 antagonist that targets anti-apoptotic members of the Bcl-2 family, including Bcl-2, Bcl-xL, and Mcl-1. By disrupting the interactions between anti-apoptotic Bcl-2 proteins and pro-apoptotic effectors, Obatoclax overcomes Mcl-1-mediated resistance to apoptosis. This inhibition leads to mitochondrial outer membrane permeabilization, cytochrome c release, and activation of caspase-dependent apoptotic pathways in various cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (198.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.