CAS No. 407-41-0

Batch: Purity:98
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O-Phospho-L-serine Chemical Structure
Chemical Structure
Check the O-Phospho-L-serine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 407-41-0
Molecular Formula

C3H8NO6P
Molecular Weight (MW) 185.07
SMILES C(C(C(=O)O)N)OP(=O)(O)O

Biological Activity

O-Phospho-L-serine is a specific group III metabotropic glutamate receptor (mGluR) agonist that mimics the phosphatidylserine head group. Activation of group III mGluRs modulates glutamatergic signaling and downstream intracellular cascades. Additionally, by mimicking phosphatidylserine, O-phospho-L-serine partially blocks microglial phagocytosis of apoptotic cells, serving as a valuable tool for investigating neuroinflammation, microglial function, and glutamatergic neurotransmission. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 37 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Schoepp DD, et al. Neuropharmacology. 1999;38(10):1431-76.

[2] Fadok VA, et al. J Immunol. 1992;148(7):2207-16.

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Note: Technical data last updated: Sep 1, 2026.