CAS No. 66638-22-0

Batch: Purity:99.82
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O-Acetyl-L-serine hydrochloride Chemical Structure
Chemical Structure
Check the O-Acetyl-L-serine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 66638-22-0
Molecular Formula

C5H10ClNO4
Molecular Weight (MW) 183.59
SMILES Cl.CC(=O)OCC(N)C(O)=O

Ordering Information

Biological Activity

O-Acetyl-L-serine hydrochloride is a key metabolic intermediate in bacterial and plant cysteine biosynthesis and functions as a regulatory signaling molecule. It triggers transcriptional changes in gene sets controlling sulfur assimilation, transport, and metabolic pathways independently of sulfur nutritional status. Increased intracellular accumulation of O-acetyl-L-serine coordinates the expression of sulfate transporters and metabolic enzymes to maintain sulfur homeostasis.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 37 mg/mL (201.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 37 mg/mL
Ethanol 37 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.