CAS No. 2649400-34-8

Batch: Purity:99.58
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NX-5948 Chemical Structure
Chemical Structure
Check the NX-5948 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[4-[1-[[1-[6-[[(3S)-2,6-dioxopiperidin-3-yl]carbamoyl]-3-pyridinyl]piperidin-4-yl]methyl]piperidin-4-yl]anilino]-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide
CAS Number 2649400-34-8
Molecular Formula

C42H54N12O5
Molecular Weight (MW) 806.96
InChIKey HPTPDBYCFHFWJG-CWTKIQHKSA-N

Ordering Information

Biological Activity

NX-5948 is an oral proteolysis targeting chimera (PROTAC) that induces selective degradation of Bruton's tyrosine kinase (BTK) by recruiting the cereblon (CRBN) E3 ubiquitin ligase complex. By promoting proteasomal BTK degradation, NX-5948 disrupts B-cell receptor (BCR) signaling and downstream survival pathways. This mechanistic depletion suppresses B-cell activation and proliferation, demonstrating potent anti-inflammatory activity, while also effectively penetrating the blood-brain barrier in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 14 mg/mL (17.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.