CAS No. 3030588-01-0
Batch:
Purity:98.68
Chemical Structure
Check the
NVS-STG2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxybenzoic acid | |
|---|---|---|
| CAS Number | 3030588-01-0 | |
| Molecular Formula |
C25H33NO5 |
|
| Molecular Weight (MW) | 427.53 | |
| InChIKey | CZSPKEVHLRWAFC-UHFFFAOYSA-N |
NVS-STG2 is an allosteric small-molecule agonist and molecular glue targeting stimulator of interferon genes (STING). By binding to a pocket between the transmembrane domains of neighboring STING dimers, it promotes high-order STING oligomerization and pathway activation. This molecular engagement triggers robust STING-mediated innate immune signaling downstream, driving type I interferon pathway responses and producing antitumor efficacy in animal models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.