CAS No. 1419949-20-4

Batch: Purity:99.85
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NVP-TNKS656 Chemical Structure
Chemical Structure
Check the NVP-TNKS656 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
CAS Number 1419949-20-4
Molecular Formula

C27H34N4O5
Molecular Weight (MW) 494.58
SMILES COC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)N(CC3CC3)CC4=NC5=C(COCC5)C(=O)N4
InChIKey DYGBNAYFDZEYBA-UHFFFAOYSA-N

Ordering Information

Biological Activity

NVP-TNKS656 is an orally bioavailable, selective tankyrase inhibitor targeting TNKS2 (IC50 6 nM) with over 300-fold selectivity against PARP1 and PARP2. By inhibiting tankyrase activity, NVP-TNKS656 blocks poly(ADP-ribosylation) and subsequent degradation of Axin proteins, thereby stabilizing Axin and suppressing canonical Wnt/beta-catenin signaling. Consequently, this pathway inhibition downregulates downstream Wnt target genes and impairs Wnt-driven cell proliferation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (202.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.